Siberian mouse chan6/12/2023 ![]() The various ginsengs demonstrated negligible effects. The possibility of eliminating interference of Chan Su on serum digoxin measurement was also investigated, by measuring free digoxin concentration after supplementing aliquots of the third digoxin pool with various amounts of Chan Su extract.Ī clinically significant interference by Chan Su with serum digoxin measurement was observed using the LOCI digoxin assay. Mice were fed Chan Su extract to determine the potential of in vivo derived interfering factors. Two digoxin pools were supplemented with these traditional medicines to investigate their effect on serum digoxin measurements. We also prepared 3 digoxin pools from patients receiving digoxin. Serum digoxin concentrations were measured using the LOCI digoxin assay on the Vista 1500 analyzer. The effects of interference by Chan Su and various ginsengs on this new immunoassay have not yet been reported.Īliquots of a drug-free serum pool were supplemented with Chan Su, Asian ginseng, Siberian ginseng, and American ginseng representing the expected in vivo concentrations after normal usage and cases of overdose. ![]() Recently, a homogeneous sequential chemiluminescent assay for digoxin based on the luminescent oxygen channeling technology (LOCI digoxin) for application on the Dimension and Vista platform has been introduced into the market. Chan Su, Asian ginseng, Siberian ginseng, and American ginseng are known to interfere with various digoxin immunoassays.
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